NaK-ATPase Background The NaK-ATPase or sodium pump is a membrane protein that hydrolyses ATP in order to drive the coupled extrusion and uptake of Na and K ions across the plasma membrane. PDF The gamma subunit of the NaK-ATPase a 7-kDa single-span membrane protein is a member of the FXYD gene family.
Sodium Potassium Pump Sodium Potassium Pump Nursing School Essential Sodium
It works constantly in the background to maintain the intracellular and extracellular sodium and potassium ion concentrations and is therefore essential for electrical activity in nerve cells see Ch.
Nak atpase. The sodium pump NaK-ATPase is responsible for two thirds of the basal energy expenditure of the brain. The sodium-potassium ATPase NaK-ATPase or NaK-pump is an enzyme present at the surface of all eukaryotic cells which actively extrudes Na from cells in exchange for K at a ratio of 32 respectively. Whenever an action potential is generated additional Na enters the cell and K leaves the cell.
It is sodium-potassium adenosine triphosphatase also known as the Na K pump sodium-potassium pump or simply sodium pump for short. This action creates the electrochemical gradient of sodium and potassium ions providing the energy for active transport of various nutrients2 Publications. It is composed of a catalytic α subunit and a β subunit reviewed in 1.
Its activity also provides the driving force for secondary active transport of solutes su. Plasma Membrane Marker NaK ATPase pan Cadherin PMCA1 Antibody Sampler Panel - Human Mouse ab254025. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients.
Select up to 5 products from below to compare or request more information. Although active transport of potassium into human platelets has been demonstrated previously there is hitherto no evidence that human platelets have an ouabain-inhibitable Na-K ATPase in their membrane. The NaK-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family.
Glioblastoma GBM is the most frequent brain cancer with poor prognosis and few therapies and urgently requires effective treatments. At less than 015 mM ATP linoleic acid stimulated NaK-ATPase but at higher ATP concentrations the enzyme was progressively inhibited. The thereby established electrochemical gradient is essential for cellular function 1.
Several FXYD proteins have been. 05091986 inhibition of NaK-ATPase by linoleic acid. Na K -ATPase Under resting conditions Na slowly leaks into the cells and K leaks out of the cell because of electrochemical driving forces.
Sponsored Products GeneTex Anti-SodiumPotassium ATPase beta 1 antibody. Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells. The NaK-ATPase was the founding member of the P-type ATPase family Skou 1957 whose members share this basic mechanism to transport numerous different cations and even lipids.
Find read and cite all the research you. It was first discovered by Jens Christian Skou who won a Nobel Prize in Chemistry in 1997. Na K -ATPase is an enzyme found in the plasma membrane.
01112019 alpha 1 Sodium Potassium ATPaseATP1A1 Antibody C4646 is recommended for detection of Na K -ATPase α1 of broad species origin by WB IP IF and IHC P. The enzyme moves Na ions out of the cell and replaces them with K ions. The NaK-ATPase is a family II P-type ATPase and is composed of a catalytic a.
Ketchem CJ 1 Conner CD 1 Murray RD 2 DuPlessis M 3 Lederer ED 4 Wilkey D 3 Merchant M 5 Khundmiri SJ 6. The antibody recognizes an extracellular epitope and could potentially be used for detecting the protein in living cells. Request Info for all products Compare.
Your search returned 609 NA K ATPase beta subunit Antibodies across 36 suppliers. 13081987 This is the catalytic component of the active enzyme which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. In summary NEFA and lysophospholipids at levels similar to those occurring in human plasma may account for all of the NaK-ATPase.
The present study demonstrates active rubidium used as an index of potassium influx 86RbK influx into platelets inhibitable by ouabain and also demonstrates the presence of. Na K -ATPase is considered as a target for GBM therapy and development of anticancer drugsCardiac glycosides bind the Na K -ATPase α subunit to inhibit enzymatic activity and are promising candidates for anticancer drug development. Showing 28 of 36 suppliers 609 products total 1.
The antibody can be used in western blot analysis. Lyophilized Anti-Beta 2 NaK ATPase extracellular Antibody ANP-012 is a highly specific antibody directed against an epitope of the rat ATP1B2.
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